his meta-analysis found that proton pump inhibitors (PPIs) had no protective effects on either high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) in patients with Barrett’s esophagus (BE).
https://www.univadis.com/viewarticle/barrett-s-esophagus-do-ppis-reduce-esophageal-cancer-risk-481424
Barrett’s esophagus: do PPIs reduce esophageal cancer risk?