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Merck (MRK) and Pfizer (PFE) Initiate Two Phase III Studies of Avelumab in Advanced GEJ Cancers

Merck KGaA (NYSE: MRK), Darmstadt, Germany, and Pfizer (NYSE: PFE) today announced the initiation of two Phase III studies of avelumab*, an investigational, fully human anti-PD-L1 IgG1 monoclonal antibody, in treating advanced or metastatic gastric/gastro-esophageal junction (GEJ) cancers, which are aggressive cancers with poor survival rates. These pivotal trials are investigating avelumab in the first-line and third-line settings, with overall survival (OS) as the primary endpoint in both trials.

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