The variable rate of missed cancer in endoscopic biopsies and lack of other biomarkers reduce the effectiveness of surveillance programmes in esophageal cancer.
http://cancerres.aacrjournals.org/content/early/2010/09/29/0008-5472.CAN-10-1566.abstract
Metabolic profiling detects field effects in non-dysplastic tissue from esophageal cancer patients