Although epidemiologic studies point to environmental factors, obesity, smoking, esophageal reflux, and diet as the main causes of Barrett’s esophagus (BE), there is growing evidence of a genetic predisposition as well. It is now fairly clear that the role of genetics is greatest in the initial stages of the disease.
https://www.news-medical.net/health/Barretts-Esophagus-Genetics.aspx
Barrett's Esophagus Genetics